2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

Related Products

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-19285R
    Sulfaclozine (Standard)
    		Inhibitor
    Sulfaclozine (Standard) is the analytical standard of Sulfaclozine. This product is intended for research and analytical applications. Sulfaclozine (Sulfachloropyrazine) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis).
    Sulfaclozine (Standard)
  • HY-182394
    DM-1157
    		Inhibitor
    DM-1157 is an orally active asymmetric bisquinoline heme inhibitor with a IC50 of 1.6 μM and a Kd of 1.7 μM. DM-1157 binds to heme dimers in solution, inhibits β-hematin formation, suppresses hemozoin formation in the digestive vacuole of Plasmodium falciparum, accumulates in the digestive vacuole of Plasmodium falciparum, induces enlargement of the digestive vacuole of Plasmodium falciparum, and inhibits the growth of Chloroquine (HY-17589A)-sensitive and resistant Plasmodium falciparum strains. DM-1157 can be used for the research of malaria and Plasmodium falciparum-type malaria.
    DM-1157
  • HY-183621
    Antileishmanial agent-43
    		Inhibitor
    Antileishmanial agent-43 is a 3,4,5‑trisubstituted isoxazole with selective antileishmanial activity. Antileishmanial agent-43 shows IC50 values of 12.7 μM against Leishmania amazonensis promastigotes and 0.96 μM against intracellular amastigotes. Antileishmanial agent-43 induces ROS elevation, oxidative stress and mitochondrial dysfunction, resulting in lipid peroxidation, mitochondrial depolarization and ATP imbalance. Antileishmanial agent-43 causes cell shrinkage, phosphatidylserine externalization, plasma membrane permeabilization, and promotes autophagy. Antileishmanial agent-43 can be used for the research of leishmaniasis.
    Antileishmanial agent-43
  • HY-12785R
    Albendazole sulfoxide (Standard)
    		Inhibitor
    Albendazole sulfoxide (Standard) is the analytical standard of Albendazole sulfoxide. This product is intended for research and analytical applications. Albendazole sulfoxide (Ricobendazole), the main active metabolite of Albendazole, exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes.
    Albendazole sulfoxide (Standard)
  • HY-W049875R
    Nitroxynil (Standard)
    		Inhibitor
    Nitroxynil (Standard) is the analytical standard of Nitroxynil. This product is intended for research and analytical applications. Nitroxynil, anthelmintic agent, is active against parasites in both adult and immature stages. Nitroxynil is widely used for the research of infection of Fasciola hepatica.
    Nitroxynil (Standard)
  • HY-N14536
    Dihydrohypothemycin
    		Inhibitor
    Dihydrohypothemycin has anti-tsutsugamushi activity.
    Dihydrohypothemycin
  • HY-170963
    LASSBio-1985
    		Inhibitor
    LASSBio-1985 is an NHLd inhibitor (nucleoside hydrolase from Leishmania donovani), with a Ki of 79 μM and an IC50 of 84.6 μM. LASSBio-1985 exhibits selective toxicity against Leishmania parasites, with no toxicity to mammalian cells, making it a promising candidate for research in the field of anti-infective therapies.
    LASSBio-1985
  • HY-19567R
    PK 11195 (Standard)
    		Inhibitor
    PK 11195 (Standard) is the analytical standard of PK 11195. This product is intended for research and analytical applications. PK 11195 (RP 52028) is a ligand of translocator protein (TSPO), which targets Leishmania chemotherapy, with IC50s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively.
    PK 11195 (Standard)
  • HY-181864
    Rac1-IN-6
    		Inhibitor
    Rac1-IN-6 (Compound 5e) is a selective Rac1 inhibitor and antimalarial agent. Rac1-IN-6 inhibits Rac1 activation induced by the Escherichia coli CNF1 toxin. Rac1-IN-6 suppresses the growth of chloroquine-sensitive Plasmodium falciparum D10 (IC50 = 76.0 nM) and chloroquine-resistant Plasmodium falciparum W2 (IC50 = 236.6 nM).
    Rac1-IN-6
  • HY-N8181
    1,3-Linolein-2-Olein
    		Inhibitor
    1,3-Linolein-2-Olein, a triglyceride, is an antileishmanial agent. 1,3-Linolein-2-Olein inhibits promatigotes of the parasite (IC50=0.079 ug/ml) and inhibits the growth of amastigotes (IC50= 40.03 ug/ml).
    1,3-Linolein-2-Olein
  • HY-50730R
    Asparagusic acid (Standard)
    		Inhibitor
    Asparagusic acid (Standard) is the analytical standard of Asparagusic acid. This product is intended for research and analytical applications. Asparagusic acid is a sulfur-containing flavor component produced by Asparagus officinalis Linn., with anti-parasitic effect. Asparagusic acid is a plant growth inhibitor.
    Asparagusic acid (Standard)
  • HY-119900R
    Carnidazole (Standard)
    		Inhibitor
    Carnidazole (Standard) is the analytical standard of Carnidazole. This product is intended for research and analytical applications. Carnidazole is an antiprotozoal agent of the nitroimidazole class. Carnidazole is used for the research of Trichomonas infection.
    Carnidazole (Standard)
  • HY-130743
    Dieugenol
    Dieugenol is a neolignan that has been found in N. leucantha and has antioxidative and antiprotozoal activities. It inhibits the formation of thiobarbituric acid reactive substances (TBARS) and scavenges superoxide anions, but not hydroxyl radicals, in cell-free assays. It has anti-trypanosomal activity against T. cruzi amastigotes and trypomastigotes (IC50s=15.1 and 11.5 μM, respectively) but is cytotoxic to NCTC L-929 fibroblasts with a 50% cytotoxic concentration (CC50) value of 58.2 μM.2 Dieugenol (15 μM) disrupts the integrity of the T. cruzi trypomastigote plasma membrane but does not induce the production of reactive oxygen species (ROS) in trypomastigotes or LPS-stimulated and unstimulated isolated mouse peritoneal macrophages.
    Dieugenol
  • HY-162572
    Bitipazone
    		Inhibitor
    Bitipazone, diacetylbis(piperidinethyl)thiourea cysteine ester (I), has potent anticoccidial activity. Bitipazone showed significant efficacy and good tolerability in rabbits and turkeys, and in chronic toxicity tests, bitipazone was tolerated in turkeys at concentrations below 90 ppm in feed. Pharmacokinetic studies show that bitipazone is eliminated slowly from the blood and organs of these animal species.
    Bitipazone
  • HY-W654221
    Hydroxychloroquine O-sulfate sodium
    Hydroxychloroquine O-Sulfate (HCQ O-Sulfate) sodium is a derivative of the antimalarial agent Hydroxychloroquine (HY-W031727).
    Hydroxychloroquine O-sulfate sodium
  • HY-16913
    Desferriferrithiocin
    		Inhibitor
    Desferriferrithiocin (CGP 23841A), a microbial iron chelator, inhibits the growth of P. falciparum in a dose dependent way.
    Desferriferrithiocin
  • HY-120316
    AB3127-C
    		Inhibitor
    AB3127-C is an anti-mite agent that can be isolated from Streptomyces platensis AB3217. AB3127-C exerts a protection coefficient of 90% at a concentration of 100 μg/mL.
    AB3127-C
  • HY-135811R
    Desethyl chloroquine (Standard)
    		Inhibitor
    Desethyl chloroquine (Standard) is the analytical standard of Desethyl chloroquine. This product is intended for research and analytical applications. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity.
    Desethyl chloroquine (Standard)
  • HY-163063
    Antimalarial agent 34
    		Inhibitor
    Antimalarial agent 34 is a modest PfARK1/3 inhibitor and shows potent antiplasmodial activity (EC50 = 0.16 μM).
    Antimalarial agent 34
  • HY-181266
    Antimalarial agent 55
    		Inhibitor
    Antimalarial agent 55 is an orally potent inhibitor of PfA-M1 and PfA-M17 aminopeptidases from Plasmodium falciparum, with Ki values of 27 nM and 81 nM, respectively. Antimalarial agent 55 exhibits potent nanomolar activity against homologous enzymes from Plasmodium vivax and Plasmodium berghei, with Ki values of 2 nM, 4 nM, 190 nM and 18 nM for Pv-M1, Pb-M1, Pv-M17 and Pb-M17, respectively. Antimalarial agent 55 possesses significant antiplasmodial activity, as well as cross-species inhibitory capacity and broad-spectrum activity that is unaffected by existing drug resistance mechanisms. Antimalarial agent 55 can be used in malaria research.
    Antimalarial agent 55
Parasite Isoform Comparison

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